TY - JOUR A1 - Weiss, Friedbert A1 - Porrino, Linda J. T1 - Behavioral Neurobiology of Alcohol Addiction: Recent Advances and Challenges Y1 - 2002/05/01 JF - The Journal of Neuroscience JO - The Journal of Neuroscience SP - 3332 EP - 3337 DO - 10.1523/JNEUROSCI.22-09-03332.2002 VL - 22 IS - 9 UR - http://www.jneurosci.org/content/22/9/3332.abstract N2 - Addictive behavior associated with alcoholism is characterized by compulsive preoccupation with obtaining alcohol, loss of control over consumption, and development of tolerance and dependence, as well as impaired social and occupational functioning. Like other addictive disorders, alcoholism is characterized by chronic vulnerability to relapse after cessation of drinking. To understand the factors that compel some individuals to drink excessively, alcohol research has focused on the identification of brain mechanisms that support the reinforcing actions of alcohol and the progression of changes in neural function induced by chronic ethanol consumption that lead to the development of dependence. More recently, increasing attention has been directed toward the understanding of neurobiological and environmental factors in susceptibility to relapse. ER -