TY  - JOUR
A1  - Steinberger, Daniela
A1  - Reynolds, David S.
A1  - Ferris, Pushpindar
A1  - Lincoln, Rachael
A1  - Datta, Susmita
A1  - Stanley, Joanna
A1  - Paterson, Andrea
A1  - Dawson, Gerard R.
A1  - Flint, Jonathan
T1  - Genetic Mapping of Variation in Spatial Learning in the Mouse
Y1  - 2003/03/15 
JF  - The Journal of Neuroscience 
JO  - The Journal of Neuroscience 
SP  - 2426 
EP  - 2433 
DO  - 10.1523/JNEUROSCI.23-06-02426.2003 
VL  - 23 
IS  - 6 
UR  - http://www.jneurosci.org/content/23/6/2426.abstract 
N2  - Inbred strains of mice are known to differ in their performance in the Morris water maze task, a test of spatial discrimination and place navigation in rodents, but the genetic basis of individual variation in spatial learning is unknown. We have mapped genetic effects that contribute to the difference between two strains, DBA/2 and C57BL6/J, using an F2 intercross and methods to detect quantitative trait loci (QTL). We found two QTL, one on chromosome 4 and one on chromosome 12, that influence behavior in the probe trial of the water maze (genome-wide significance p = 0.017 and 0.015, respectively). By including tests of avoidance conditioning and behavior in a novel environment, we show that the QTL on chromosomes 4 and 12 specifically influence variation in spatial learning. QTL that influence differences in fearful behavior (on chromosomes 1, 3, 7, 15, and 19) operate while mice are trained in the water maze apparatus. 
ER  -