TY  - JOUR
A1  - Huang, Yunfei
A1  - Kang, Bingnan N.
A1  - Tian, Jing
A1  - Liu, Yi
A1  - Luo, Hongbo R.
A1  - Hester, Lynda
A1  - Snyder, Solomon H.
T1  - The Cationic Amino Acid Transporters CAT1 and CAT3 Mediate NMDA Receptor Activation-Dependent Changes in Elaboration of Neuronal Processes via the Mammalian Target of Rapamycin mTOR Pathway
Y1  - 2007/01/17 
JF  - The Journal of Neuroscience 
JO  - The Journal of Neuroscience 
SP  - 449 
EP  - 458 
DO  - 10.1523/JNEUROSCI.4489-06.2007 
VL  - 27 
IS  - 3 
UR  - http://www.jneurosci.org/content/27/3/449.abstract 
N2  - Neuronal activity influences protein synthesis and neuronal growth. Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth. We show that NMDA receptor activation markedly reduces arginine transport by decreasing surface expression of the cationic amino acid transporters (CAT) 1 and 3. Depletion of CAT1 and CAT3 by RNA interference blocks influences of NMDA receptor activation on the mTOR pathway and neuronal process formation. Thus, the CATs mediate influences of NMDA receptor activation on the mTOR pathway that regulates neuronal processes. 
ER  -