AU - Fried, Itzhak AU - Haggard, Patrick AU - He, Biyu J. AU - Schurger, Aaron TI - Volition and Action in the Human Brain: Processes, Pathologies, and Reasons PT - JOURNAL ARTICLE DP - 2017 Nov 08 TA - The Journal of Neuroscience PG - 10842-10847 VI - 37 IP - 45 4099 - http://www.jneurosci.org/content/37/45/10842.abstract 4100 - http://www.jneurosci.org/content/37/45/10842.full SO - J. Neurosci. 2017 Nov 08; 37(45):10842-10847 AID - 10.1523/JNEUROSCI.2584-17.2017 [doi] ABĀ  - Humans seem to decide for themselves what to do, and when to do it. This distinctive capacity may emerge from an ability, shared with other animals, to make decisions for action that are related to future goals, or at least free from the constraints of immediate environmental inputs. Studying such volitional acts proves a major challenge for neuroscience. This review highlights key mechanisms in the generation of voluntary, as opposed to stimulus-driven actions, and highlights three issues. The first part focuses on the apparent spontaneity of voluntary action. The second part focuses on one of the most distinctive, but elusive, features of volition, namely, its link to conscious experience, and reviews stimulation and patient studies of the cortical basis of conscious volition down to the single-neuron level. Finally, we consider the goal-directedness of voluntary action, and discuss how internal generation of action can be linked to goals and reasons.