RT Journal
A1 Millevert, Charissa
A1 Vidas-Guscic, Nicholas
A1 Vanherp, Liesbeth
A1 Jonckers, Elisabeth
A1 Verhoye, Marleen
A1 Staelens, Steven
A1 Bertoglio, Daniele
A1 Weckhuysen, Sarah
T1 Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents
JF The Journal of Neuroscience 
JO The Journal of Neuroscience 
YR 2023 
FD December 06 
VO 43 
IS 49 
SP 8275 
OP 8293 
DO 10.1523/JNEUROSCI.1043-23.2023 
UL http://www.jneurosci.org/content/43/49/8275.abstract 
AB Neurodevelopmental disorders (NDDs) are a group of complex neurologic and psychiatric disorders. Functional and molecular imaging techniques, such as resting-state functional magnetic resonance imaging (rs-fMRI) and positron emission tomography (PET), can be used to measure network activity noninvasively and longitudinally during maturation in both humans and rodent models. Here, we review the current knowledge on rs-fMRI and PET biomarkers in the study of normal and abnormal neurodevelopment, including intellectual disability (ID; with/without epilepsy), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD), in humans and rodent models from birth until adulthood, and evaluate the cross-species translational value of the imaging biomarkers. To date, only a few isolated studies have used rs-fMRI or PET to study (abnormal) neurodevelopment in rodents during infancy, the critical period of neurodevelopment. Further work to explore the feasibility of performing functional imaging studies in infant rodent models is essential, as rs-fMRI and PET imaging in transgenic rodent models of NDDs are powerful techniques for studying disease pathogenesis, developing noninvasive preclinical imaging biomarkers of neurodevelopmental dysfunction, and evaluating treatment-response in disease-specific models.