@article{Marshall10042024,
author = {Marshall, Paul R. and Davies, Joshua and Zhao, Qiongyi and Liau, Wei-Siang and Lee, Yujin and Basic, Dean and Periyakaruppiah, Ambika and Zajaczkowski, Esmi L. and Leighton, Laura J. and Madugalle, Sachithrani U. and Musgrove, Mason and Kielar, Marcin and Brueckner, Arie Maeve and Gong, Hao and Ren, Haobin and Walsh, Alexander and Kaczmarczyk, Lech and Jackson, Walker S. and Chen, Alon and Spitale, Robert C. and Bredy, Timothy W.}, 
title = {DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory},
volume = {44}, 
number = {15}, 
year = {2024}, 
doi = {10.1523/JNEUROSCI.0093-23.2024}, 
abstract ={The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation.One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory.}, 
URL = {http://www.jneurosci.org/content/44/15/e0093232024.abstract}, 
eprint = {http://www.jneurosci.org/content/44/15/e0093232024.full.pdf+html}, 
journal = {The Journal of Neuroscience} 
}