TY  - JOUR
A1  - Marshall, Paul R.
A1  - Davies, Joshua
A1  - Zhao, Qiongyi
A1  - Liau, Wei-Siang
A1  - Lee, Yujin
A1  - Basic, Dean
A1  - Periyakaruppiah, Ambika
A1  - Zajaczkowski, Esmi L.
A1  - Leighton, Laura J.
A1  - Madugalle, Sachithrani U.
A1  - Musgrove, Mason
A1  - Kielar, Marcin
A1  - Brueckner, Arie Maeve
A1  - Gong, Hao
A1  - Ren, Haobin
A1  - Walsh, Alexander
A1  - Kaczmarczyk, Lech
A1  - Jackson, Walker S.
A1  - Chen, Alon
A1  - Spitale, Robert C.
A1  - Bredy, Timothy W.
T1  - DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory
Y1  - 2024/04/10 
JF  - The Journal of Neuroscience 
JO  - The Journal of Neuroscience 
DO  - 10.1523/JNEUROSCI.0093-23.2024 
VL  - 44 
IS  - 15 
UR  - http://www.jneurosci.org/content/44/15/e0093232024.abstract 
N2  - The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation.One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory. 
ER  -