AU  - Marshall, Paul R.
AU  - Davies, Joshua
AU  - Zhao, Qiongyi
AU  - Liau, Wei-Siang
AU  - Lee, Yujin
AU  - Basic, Dean
AU  - Periyakaruppiah, Ambika
AU  - Zajaczkowski, Esmi L.
AU  - Leighton, Laura J.
AU  - Madugalle, Sachithrani U.
AU  - Musgrove, Mason
AU  - Kielar, Marcin
AU  - Brueckner, Arie Maeve
AU  - Gong, Hao
AU  - Ren, Haobin
AU  - Walsh, Alexander
AU  - Kaczmarczyk, Lech
AU  - Jackson, Walker S.
AU  - Chen, Alon
AU  - Spitale, Robert C.
AU  - Bredy, Timothy W.
TI  - DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory
PT  - JOURNAL ARTICLE
DP  - 2024 Apr 10 
TA  - The Journal of Neuroscience 
VI  - 44 
IP  - 15 
4099 - http://www.jneurosci.org/content/44/15/e0093232024.abstract 
4100 - http://www.jneurosci.org/content/44/15/e0093232024.full 
SO - J. Neurosci. 2024 Apr 10; 44(15)
AID  - 10.1523/JNEUROSCI.0093-23.2024 [doi] 
AB  - The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation.One-Sentence Summary: G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory.