TY  - JOUR
A1  - Qi, Song
A1  - Cross, Logan
A1  - Wise, Toby
A1  - Sui, Xin
A1  - O’Doherty, John
A1  - Mobbs, Dean
T1  - The Role of the Medial Prefrontal Cortex in Spatial Margin of Safety Calculations
Y1  - 2024/08/21 
JF  - The Journal of Neuroscience 
JO  - The Journal of Neuroscience 
DO  - 10.1523/JNEUROSCI.1162-22.2024 
VL  - 44 
IS  - 34 
UR  - http://www.jneurosci.org/content/44/34/e1162222024.abstract 
N2  - Naturalistic observations show that animals pre-empt danger by moving to locations that increase their success in avoiding future threats. To test this in humans, we created a spatial margin of safety (MOS) decision task that quantifies pre-emptive avoidance by measuring the distance subjects place themselves to safety when facing different threats whose attack locations vary in predictability. Behavioral results show that human participants place themselves closer to safe locations when facing threats that attack in spatial locations with more outliers. Using both univariate and multivariate pattern analysis (MVPA) on fMRI data collected during a 2 h session on participants of both sexes, we demonstrate a dissociable role for the vmPFC in MOS-related decision-making. MVPA results revealed that the posterior vmPFC encoded for more unpredictable threats with univariate analyses showing a functional coupling with the amygdala and hippocampus. Conversely, the anterior vmPFC was more active for the more predictable attacks and showed coupling with the striatum. Our findings converge in showing that during pre-emptive danger, the anterior vmPFC may provide a safety signal, possibly via foreseeable outcomes, while the posterior vmPFC drives unpredictable danger signals. 
ER  -