Table 1.
Treatment paradigms for chronic intraperitoneal injections of rats (see Fig. 2)
| Day of treatment | Days 1–11 | Day 12 | |||
|---|---|---|---|---|---|
| Group | Initial | 15 min later | Initial | 15 min later | |
| 1 | Saline | Saline | Saline | Saline | Control |
| 2 | Saline | Saline | Saline | Amph* | Acute amph |
| 3 | MK-801 | Saline | MK-801 | Saline | Chronic MK-801 |
| 4 | Saline | Amph | Saline | Amph | Chronic amph |
| 5 | MK-801 | Amph | MK-801 | Amph | Chronic amph blocked by MK-801 |
| 6 | MK-801 | Amph | Saline | Amph | Chronic amph blocked by MK-801, unblocked at last injection |
-
*Amph, S(+)-amphetamine sulfate. Drug concentrations: amph, 4 mg/kg; MK-801, 1 mg/kg.
