Effect of MK-801 on cell death in the EGL after GCV treatment. Animals were treated with GCV and either PBS or MK-801 at P5, and tissue was taken for analysis 48 hr later. Each panel shows a photomicrograph of an H&E-stained paraffin section through the base of the cerebellar folia between the culmen and declive, near the midline. a, Nontransgenic mouse treated with GCV and MK-801 at P5, 48 hr survival; the EGL is 7–9 layers thick.b, TgN5Mes treated with GCV and PBS; the EGL is 0–3 layers thick. c, TgN5Mes treated with GCV and MK-801; the EGL is 5–9 layers thick. Scale bar, 50 μm.