Expression of HGF/SF, c-met, and tPA in the developing olfactory system at E18. The left panels are bright-field images, and the right panels are corresponding dark-field images. Hybridization of35S-labeled antisense cRNA probes with E18 sagittal sections. A, HGF/SF expression is observed in the OM of the developing nasal cavity. In the developing bulb, expression of HGF/SF is high in the SVZ of the LVs and OVs including the RMS (indicated by arrows) extending from the LV into the olfactory bulb. B, Expression of c-metoccurs in the ON and MCL. C, Expression of tPA is high in the M and coincident with HGF/SF expression in the SVZ and RMS (indicated by arrows). Scale bar, 280 μm. See legend to Figure 3 for abbreviations.
