Dopamine turnover as determined by the DOPAC-to-dopamine (DA) ratio in the prefrontal cortex, nucleus accumbens, and striatum of rats. A, Rats were pretreated with systemic injections of either (+)HA966 [(+)HA; 20 mg/kg] or vehicle at 45 min and FG7142 (FG; 20 mg/kg) or vehicle (VEH) at 30 min before killing. B,Rats were pretreated with infusions into the ventral tegmental area of either (+)HA966 [(+)HA; 15 μg in 1 μl] or vehicle at 45 min and FG7142 (FG; 20 mg/kg) or vehicle (VEH) at 30 min before killing. Data are expressed as mean ± SEM. *p < 0.05 versus vehicle.