Characterization of Intrastriatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer of Human Tyrosine Hydroxylase and Human GTP-Cyclohydrolase I in a Rat Model of Parkinson’s Disease

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Fig. 4.
Fig. 4.

Striatal TH+ cell counts taken from animals infected with rAAV–MD–hTH 3 weeks and 6 months previously. The mean Abercrombie corrected TH+ cell counts (+ SEM) from animals processed 3 weeks after transduction with rAAV–MD–TH is represented by the black bar, and the mean corrected cell counts from rAAV-transduced animals allowed to survive 6 months is represented by the open bar. Theasterisk indicates a significant reduction of the number of TH+ cells at 6 months (p = 0.05).

  1. The Journal of Neuroscience vol. 18 no. 11 4271-4284
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