Ceramide Inhibits Inwardly Rectifying K+ Currents via a Ras- and Raf-1-Dependent Pathway in Cultured Oligodendrocytes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Fig. 3.
Fig. 3.

Cer inhibits IKir in cultured rat OLGs. A, Cer (10 μm) induced a decrease in IKir amplitudes at 5 min after perfusion. Step pulses ranging from −120 to 80 mV in 20 mV increments were applied for 360 msec from holding potential of −40 mV. The pipette solution contained 140 mm Cs+instead of K+. Bath solutions contained 5.4 mm K+. B, The correspondingI–V plots.

  1. The Journal of Neuroscience vol. 18 no. 21 8712-8719
Responses to This Article
Be the first to respond to this article
Advertisement