
Cer inhibits IKir in cultured rat OLGs. A, Cer (10 μm) induced a decrease in IKir amplitudes at 5 min after perfusion. Step pulses ranging from −120 to 80 mV in 20 mV increments were applied for 360 msec from holding potential of −40 mV. The pipette solution contained 140 mm Cs+instead of K+. Bath solutions contained 5.4 mm K+. B, The correspondingI–V plots.




