cAMP-sensitive outward currents indnc neurons and wt neurons exposed chronically to X-cAMP. cAMP-sensitive currents in records labeled 3were obtained by subtraction from control record in 1and record obtained after exposure to X-cAMP in 2.A, Top record, Abolishment of slowly inactivating outward current by X-cAMP in type I neuron fromdnc. Bottom record, blockade of outward currents by 100 μm 4-AP in type I dncneuron. Inset, Distribution of inactivation times indnc neurons exhibiting single exponential inactivation. The distribution displays a single peak and is well fitted to a single Gaussian component and peaks at 91.6 msec (n = 38; r2 = 0.97). B, Properties of cAMP-modulated currents in dnc neurons. Top record, Abolishment of slowly inactivating outward current by X-cAMP in type IV neurons from dnc. Bottom record, Blockade by 100 μm 4-AP of slowly inactivating outward current in type IV neuron from dnc. C, 4-AP-sensitive outward currents in wt neuron after chronic exposure to X-cAMP. D, cAMP-sensitive, slowly inactivating outward current component in dnc mrb neuron.
