The Pharmacology and Roles of two K+ Channels in Motor Pattern Generation in the Xenopus Embryo

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Fig. 1.
Fig. 1.

The potassium currents of CPG neurons are faster than RB sensory neurons. A1, From a holding potential of −50 mV a CPG (commissural) neuron was depolarized to 10 mV for 20 msec and repolarized to −30 mV (traces are averages of 7 leak-subtracted sweeps). The inset shows the current during the step. The tail current (bottom left) was fitted by the equation I = 22 + 1320(exp(−t/0.9)) + 317(exp(−t/12.1)).Solid lines show the exponential fits of the fast, slow, and total currents. A2, Same asA1 for an RB neuron. The tail currentI = 119 + 321(exp(−t/3.8)) + 174(exp(−t/24.9)). B, C, Summary of fitted time constants for the fast and slow components, respectively, for the different cell types (Co, commissural;Mo, monopolar; Mu, multipolar). Error bars indicate 1 SEM in this and, unless otherwise specified, subsequent figures. The sample size for each class is indicated. Significance levels of comparisons in this and subsequent figures: *p < 0.05; **p < 0.01; ***p < 0.001.  

  1. The Journal of Neuroscience vol. 18 no. 4 1602-1612
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