Relative levels of mRNAs encoding the NMDA receptor subunits NR1, NR2A, NR2B, and NR2C expressed relative to α-subunits of GABA_A receptor. A, NR1 mRNA levels are unaltered in ADC-LO and ADC-HI neurons relative to SHAM and ADX control neurons. B, NR2A mRNA levels are unaltered between ADX and SHAM neurons (p < 0.05). However, ADC-LO neurons express significantly higher levels of NR2A mRNA relative to ADX neurons (p < 0.05). Levels of NR2A mRNA in ADC-HI neurons are not significantly different from those expressed by SHAM, ADX, or ADC-LO neurons. Astar indicates a significant difference from SHAM and ADX. C, NR2B mRNA levels are unaltered between ADX and SHAM-dispersed CA1 neurons. Levels of NR2B mRNA are significantly lower in ADC-LO relative to SHAM and ADX neurons (p < 0.05). NR2B mRNA levels are significantly higher in ADC-HI neurons relative to ADC-LO neurons (p < 0.001). A starindicates a significant difference from SHAM, ADX, and ADC-HI.D, The ratio of NR2A to NR2B mRNA levels is statistically indistinguishable among dispersed CA1 neurons from the SHAM, ADX, and ADC-HI treatment groups. This ratio is significantly higher in ADC-LO neurons relative to other treatment groups (p < 0.05). A star indicates a significant difference from SHAM, ADX, and ADC-HI.