The weaver Mouse gain-of-functionPhenotype of Dopaminergic Midbrain Neurons Is Determined by Coactivation of wvGirk2 and K-ATP Channels

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Fig. 1.
Fig. 1.

Electrophysiological phenotype of (wv/wv) dopaminergic SN neurons. A,B, Standard whole-cell current-clamp recordings of spontaneous electrical activity in dopaminergic SN neurons of wild-type (+/+) and homozygotic weaver (wv/wv) mouse.C, D, Responses of membrane potential to injection of hyperpolarizing currents of increasing amplitudes from −25 to −150 pA in steps of 25 pA in (+/+) and (wv/wv) dopaminergic SN neurons. E, F, Current response to voltage ramps from −120 to −40 mV from a holding potential of −60 mV in (+/+) and (wv/wv) dopaminergic SN neurons.Dotted lines indicate zero levels.

  1. The Journal of Neuroscience vol. 19 no. 20 8839-8848
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