Increased expression of laminin receptors at the cell surface is associated with increased neuronal adhesion and outgrowth. Means + SEMs from three experiments are given.A, Neurons expressing high levels of integrin α3 and α6 at the cell surface (Low LM Cultured andPG/LM Cultured) show increased adhesion to laminin and to PG/LM substrata. *Different from LM cultured atp < 0.1 (t test). Values for all other low laminin-cultured and PG/LM-cultured conditions are significantly different from LM cultured at p < 0.05 or better. B, Neurons expressing high levels of integrin α3 and α6 at the cell surface extend neurites more readily on laminin both in the presence and absence of the growth inhibitor aggrecan. *Different from LM cultured at p < 0.1. **Significantly different from LM cultured at p < 0.005. Where error bars do not appear, they are <1%.