Inhibition of the cAMP Pathway Decreases Early Long-Term Potentiation at CA1 Hippocampal Synapses

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Fig. 4.
Fig. 4.

The AC inhibitor SQ 22536 inhibited early LTP induced by three tetani. The LTP induced by three tetani was significantly larger than the LTP induced by a single tetanus (p < 0.05). AC inhibitor SQ 22536 (100 μm) inhibited the early LTP induced by three tetani (p < 0.001; n = 7).Insets represent averaged (n = 6) fEPSP from individual experiments taken at 5 min before and 30 min after the tetanus. All calculations and markings are as in Figure 1. Field EPSP between tetani are not shown.

  1. The Journal of Neuroscience vol. 20 no. 12 4446-4451
Responses to This Article
Be the first to respond to this article
Advertisement