Phosphorylation of CREB after induction of LTP and in the presence of SL327. a, b, An increase in p-CREB labeling was observed on the potentiated side at LTP 0 compared with the contralateral dentate gyrus. c,d, Western blots confirm that p-CREB is increased only at this time point compared with control rats, and quantification showed that this was a significant increase. e,f, The level of p-CREB was greatly attenuated in SL327-treated rats compared with DMSO controls.