Centrifugal Pathways Protect Hearing Sensitivity at the Cochlea in Noisy Environments That Exacerbate the Damage Induced by Loud Sound

Table 1.

Test groups and experimental conditions of laterality of loud tone exposure (loud tone always at 13 kHz, 100 dB SPL for 10 min) and background to exposure

Group Status of efferent pathways [All pathways intact/All pathways cut/Only crossed pathways cut (leaving intact uncrossed pathways)] Loud tone exposure laterality Background to the tone exposure
Groups to establish the basic protective effects of cochlear efferents
 Silence 1 All pathways intact Monaural Silence
 Silence 2 All pathways intact Binaural Silence
 Silence 3 Ear 1: all pathways intact Binaural Silence
Ear 2: all pathways cut
 Silence 4 Ear 1: only crossed pathways cut Binaural Silence
Ear 2: only crossed pathways cut
Groups to establish that cochlear efferents provide extra protection in noise backgrounds
 Noise 1 Ear 1: all pathways intact Binaural Binaural Noise @ 40 dB SPL
Ear 2: all pathways cut
 Noise 2 Ear 1: all pathways intact Binaural Binaural Noise @ 60 dB SPL
Ear 2: all pathways cut
 Noise 3 Ear 1: all pathways intact Binaural Binaural Noise @ 80 dB SPL
Ear 2: all pathways cut
Groups to establish the role of uncrossed pathways in extra protection by cochlear efferents in noise background
 Noise 4 Ear 1: only crossed pathways cut Binaural Binaural Noise @ 80 dB SPL
Ear 2: only crossed pathways cut
 Noise 5 Ear 1: only crossed pathways cut Binaural Binaural Noise @ 80 dB SPL
Ear 2: all pathways cut
 Noise 6 All pathways intact Monaural Monaural Noise @ 80 dB SPL
 Noise 7 Ear 1: only crossed pathways cut Monaural Monaural Noise @ 80 dB SPL
Ear 2: all pathways cut Monaural Monaural Noise @ 80 dB SPL
  1. The Journal of Neuroscience vol. 20 no. 17 6684-6693
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