Muscarinic Stimulation of α1E Ca Channels Is Selectively Blocked by the Effector Antagonist Function of RGS2 and Phospholipase C-β1

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Fig. 4.
Fig. 4.

Stimulation of α1E is selectively blocked by PLCβ1ct, RGS2, and RGS8. A, Modulation of α1E by M1 receptors in a control cell. C = 16 pF;RS = 2.8 MΩ. B, Modulation of α1E by M1 receptors in a cell coexpressing PLCβ1ct. C = 24 pF; RS = 1.3 MΩ. C, Modulation of α1E by M1 receptors in a cell coexpressing RGS2.C = 11 pF; RS = 5.1 MΩ. D, Modulation of α1E by M1 receptors in a cell coexpressing RGS8. C = 13 pF;RS = 2.9 MΩ. Other details are as in Figure1.

  1. The Journal of Neuroscience vol. 20 no. 19 7167-7173
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