Motivational Effects of Ethanol in DARPP-32 Knock-Out Mice

Table 1.

Mean (±SEM) number of ethanol bouts, number of water bouts, and number of food bouts during phases 1–3

Genotype Session
1–4 5–8 9–12 13–16 17–20
Phase 1
 Ethanol bouts
  KO 2.0  (0.4) 2.2  (0.7) 2.3  (0.8) 3.4  (1.2) 3.9  (1.1)
  WT 4.1  (0.9) 4.1  (1.3) 5.0  (1.5) 7.4  (1.9) 8.0  (2.1)
 Food bouts
  KO 52.6  (2.8) 43.0  (1.8) 45.2  (1.6) 45.3  (1.9) 42.9  (1.3)
  WT 50.3  (1.6) 48.1  (1.5) 43.9  (1.9) 49.0  (1.6) 50.0  (1.5)
 Water bouts
  KO 41.2  (2.7) 34.0  (2.2) 35.5  (3.2) 35.7  (4.4) 34.9  (3.6)
  WT 36.1  (2.1) 33.7  (1.5) 33.7  (3.5) 33.3  (2.7) 31.0  (2.8)
Ethanol (% v/v)
0 5 10 20 30
Phase 2
 Ethanol bouts
  KO 2.4  (0.5) 3.8  (1.1) 4.1  (1.4) 3.3  (1.0) 3.8  (0.7)
  WT 3.8  (0.8) 6.3  (1.9) 7.7  (2.1) 8.9  (1.6) 7.7  (1.3)
 Food bouts
  KO 43.8  (2.9) 43.2  (1.7) 43.8  (2.2) 43.5  (2.5) 43.4  (1.0)
  WT 51.7  (2.2) 51.8  (1.9) 51.5  (2.7) 50.5  (1.6) 49.0  (1.9)
 Water bouts
  KO 37.3  (4.1) 34.1  (3.8) 33.5  (4.7) 35.2  (3.5) 35.5  (2.2)
  WT 40.2  (3.0) 33.7  (2.4) 32.8  (3.1) 30.0  (2.8) 35.2  (2.3)
Ethanol (% v/v)
0 5 10 20
Phase 3
 Ethanol bouts
  KO 15.4  (1.8) 20.1  (2.0) 19.9  (1.5) 15.5  (1.6)
  WT 27.1  (4.1) 31.8  (3.8) 30.2  (4.4) 24.0  (3.9)
 Food bouts
  KO 57.3  (1.8) 46.8  (2.2) 44.7  (2.6) 42.0  (1.9)
  WT 62.3  (2.2) 55.0  (1.1) 53.8  (1.6) 53.2  (2.2)
 Water bouts
  KO 34.3  (3.8) 18.6  (3.2) 16.9  (2.6) 20.7  (2.8)
  WT 20.7  (4.5) 12.2  (2.7) 10.4  (2.6) 18.1  (3.9)
  1. The Journal of Neuroscience vol. 21 no. 1 340-348
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