Expression of dominant-negative ezrins prolongs survival of U87MG human glioma xenograft-bearing athymic mice. U87MG neo, U87MG F353-ezrin, or U87MG nter-ezrin human glioma cells were implanted stereotactically into the striatum of athymic mice as detailed in Materials and Methods. A, Mice (n = 3) were killed when the first animal developed symptoms (at 28 d). Brains were fixed, cut, and tumor volumes of hematoxylin–eosin-stained brains were determined with the MCID digitalization system (*p < 0.05;n = 3; t test). B, In an independent set of experiments, the animals of each group (n = 6) were observed at regular intervals until they developed neurological symptoms. Then the mice were killed.