Kainate Receptors Expressed by a Subpopulation of Developing Nociceptors Rapidly Switch from High to Low Ca2+Permeability

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Fig. 6.
Fig. 6.

Many LA4- and LD2-positive DRG neurons express kainate receptors, but SSEA4- and substance P-positive DRG neurons do not. A, The table summarizes laminar projections and relevant functions or properties of the DRG neurons identified by the individual markers. References are given in Results. B, The percentage of total neurons expressing each marker is shown. Only cells tested with kainate application are included. C, The percentage of kainate-responsive neurons expressing each marker is shown. Over 90% of the total kainate-responsive neurons also expressed LA4. D, The percentage of neurons showing sensitivity to kainate within each labeled subpopulation is shown. Over 90% of the LD2-positive neurons have kainate responses. All data are from P1 acutely dissociated DRG neurons. Numbers above eachbar indicate the number of cells over the total.FRAP, Fluoride-resistant acid phosphatase;SubP, substance P.

  1. The Journal of Neuroscience vol. 21 no. 13 4572-4581
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