Kainate Receptors Expressed by a Subpopulation of Developing Nociceptors Rapidly Switch from High to Low Ca2+Permeability

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Fig. 7.
Fig. 7.

One hundred percent of the DRG neurons expressing kainate receptors are included in the LA4 and LD2-labeled subpopulation both at P1 and P6. A, Five of eight P6 DRG neurons show Ca2+ responses to kainate, whereas three do not. B, The cells were fixed and then stained with both LA4 and LD2. Seven of eight neurons show a positive staining with LA4 and LD2. One large DRG neuron on the top leftshows negative staining with LA4 and LD2 and no Ca2+response to kainate. C, The percentages of kainate-responsive neurons are similar in P1 and P6 DRG neurons.D, All of the kainate-responsive neurons show expression of LA4 and LD2 in P1 and P6. The numbers above eachbar represent the number of positive neurons over the total.

  1. The Journal of Neuroscience vol. 21 no. 13 4572-4581
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