Protection by MnTE-2-PyP⁵⁺ when given 6 hr after ischemia. Cerebral infarct volumes and neurologic scores were measured 7 d after a 90 min episode of transient middle cerebral artery occlusion. At 6 hr after ischemia, MnTE-2-PyP⁵⁺ (300 ng) or vehicle was injected into the left lateral ventricle (n = 16 per group). MnTE-2-PyP⁵⁺ reduced infarct size (subcortex,p = 0.03; cortex, p = 0.03) and improved neurologic score (18 = normal) (p = 0.05). Open circlesrepresent values for individual rats. Horizontal linesdepict group mean values for infarct size and median values for neurologic score.