Table 2.
Physiologic values for experiment 1 (rat focal ischemia–intracerebroventricular MnTE-2-PyP5+ before treatment)
| Vehicle (n = 14) | MnTE-2-PyP5+ 150 ng (n = 14) | MnTE-2-PyP5+ 300 ng (n = 13) | |
|---|---|---|---|
| Preischemia body weight (gm) | 290 ± 13 | 286 ± 10 | 289 ± 15 |
| Day 7 body weight (gm) | 257 ± 54 | 302 ± 22* | 306 ± 36* |
| 10 min before ischemia | |||
| MAP (mmHg) | 83 ± 19 | 91 ± 15 | 84 ± 15 |
| Arterial pH | 7.40 ± 0.04 | 7.41 ± 0.03 | 7.40 ± 0.03 |
| PaCO2(mmHg) | 39 ± 3 | 38 ± 2 | 38 ± 4 |
| PaO2(mmHg) | 154 ± 23 | 184 ± 38 | 178 ± 34 |
| Glucose (mg/dl) | 112 ± 11 | 109 ± 15 | 96 ± 16 |
| Hematocrit (%) | 39 ± 1 | 40 ± 1 | 40 ± 2 |
| Pericranial temperature (°C) | 37.5 ± 0.1 | 37.5 ± 0.1 | 37.5 ± 0.2 |
| 45 min after onset of ischemia | |||
| MAP (mmHg) | 91 ± 21 | 94 ± 23 | 102 ± 12 |
| Arterial pH | 7.39 ± 0.04 | 7.40 ± 0.05 | 7.39 ± 0.03 |
| PaCO2(mmHg) | 40 ± 5 | 39 ± 4 | 40 ± 3 |
| PaO2(mmHg) | 200 ± 36 | 211 ± 30 | 209 ± 33 |
| Pericranial temperature (°C) | 37.6 ± 0.1 | 37.6 ± 0.1 | 37.6 ± 0.1 |
| 10 min after termination of ischemia | |||
| MAP (mmHg) | 76 ± 21 | 74 ± 21 | 66 ± 11 |
| Arterial pH | 7.41 ± 0.05 | 7.43 ± 0.05 | 7.44 ± 0.03 |
| PaCO2 (mmHg) | 38 ± 5 | 36 ± 5 | 34 ± 4 |
| PaO2 (mmHg) | 194 ± 21 | 224 ± 38 | 213 ± 25 |
| Pericranial temperature (°C) | 37.6 ± 0.1 | 37.5 ± 0.1 | 37.5 ± 0.1 |
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All values are mean ± SD. MAP, Mean arterial pressure; PaCO2, arterial carbon dioxide partial pressure; PaO2, arterial oxygen partial pressure.
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↵* p < 0.01 versus vehicle group.
