Hippocampal IEG RNA expression after spatial and cued water-task training. Rats were trained in either the spatial or cued water tasks and killed 30 min later. IEG RNA levels from dorsal hippocampus were analyzed by RPA. A, Acquisition data for rats trained in each task. Performance, as measured by latency to mount the hidden (spatial) or visible (cued) platform, was not different between the two groups (p = 0.24, repeated measures ANOVA). B, Hippocampal IEG RNA levels for rats trained in both tasks were significantly above caged control levels (p < 0.001, Mann–WhitneyU test) but were not different from each other.C, D, Negative correlation between hippocampal Arc RNA levels and performance in the spatial (C), but not cued (D), water task. See Results for additional information. The Spearman correlation coefficient (R_S) is indicated for both cued and spatial trained groups (*p < 0.05).n = 8–9 rats per group.