Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors

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Fig. 7.
Fig. 7.

Withdrawal of d,l-APV significantly increased the frequency of mEPSC responses. A, Left, Ten representative consecutive traces recorded from a neuron after 15 min of incubation in aCSF in the presence of d,l-APV. A, Right, Ten similar traces after incubation in aCSF in the absence of d,l-APV. B, Withdrawal ofd,l-APV significantly increased the frequency of mEPSC responses (filled bars) compared with control (open bars). TTX and 0 mmCa2+ blocked this increase. C, Withdrawal of d,l-APV had a negligible effect on the peak amplitude (left) and the rise time and decay time (right) of EPSC responses. D, The probability of mEPSC responses over a wide range of peak amplitudes. In all, 50 consecutive sweeps were selected from each recorded neuron and pooled to calculate the probability for mEPSC responses occurring at each 1 pA interval of peak amplitude. **p < 0.01.

  1. The Journal of Neuroscience vol. 21 no. 16 6008-6017
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