Weight change of mice. Bar graphs illustrate average body weight of T44+/−: WT, T44;NFL−/−: NFL−/−, and T44;NFH−/−: NFH−/−, respectively, at 12 months of age. T44 Tg mice weighed 35% less than WT littermates, although similar weight loss was no longer observed after crossbreeding T44 mice with NFL−/− mice. More modest (8%) but significant weight loss was observed in T44;NFH−/− mice (n = 8–12).