Endogenous Activation of Group-I Metabotropic Glutamate Receptors Is Required for Differentiation and Survival of Cerebellar Purkinje Cells

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Fig. 5.
Fig. 5.

Purkinje cell morphology in cultures treated as follows. A, C,F, Cultures treated with culture medium (A), 30 μm MPEP (C), or 30 μm CPCCOEt (F) from 6 to 9 DIV and examined at 9 DIV;B, D, G, Cultures treated with culture medium (B), MPEP (D), or CPCCOEt (G) from 6 to 14 DIV and examined at 14 DIV; E, H, cultures treated with MPEP (E) or CPCCOEt (H) from 6 to 9 DIV, extensively washed (wo), and then examined at 14 DIV. Scale bar, 50 μm. Note that Purkinje cells partially recover their morphology after 5 d of drug washout (E,H).

  1. The Journal of Neuroscience vol. 21 no. 19 7664-7673
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