Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

Table 2.

Modified and unmodified Aβ in AD and Tg2576 mouse brain

Brain n Aβ 70% FA (pmol/gm) Total (pmol/gm) Modified
Tg2576 21–23 months 5 Aβ1-42 3409  ± 64 26,076
Aβ1-40 22,667  ± 440
AβX-42 1379  ± 38 27,318 5%
AβX-40 25,939  ± 1751
AD Substantial Congophilic. Angiopathy 6 Aβ1-42 826  ± 119 5827
Aβ1-40 5001  ± 2164
AβX-42 5089  ± 409 18,696 69%
AβX-40 13,607  ± 3397
AD Minimal Congophilic. Angiopathy 9 Aβ1-42 714  ± 68 746
Aβ1-40 32  ± 7
AβX-42 4663  ± 421 4879 85%
AβX-40 216  ± 38
  1. The Journal of Neuroscience vol. 21 no. 2 372-381
Responses to This Article
Be the first to respond to this article
Advertisement