Mode and Tempo of Tangential Cell Migration in the Cerebellar External Granular Layer

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Fig. 7.
Fig. 7.

Slowly migrating granule cell with descending processes near the EGL–ML border. A, The highly motile processes having lamellipodia-like structure (open arrows) and filopodia (white arrows), extended from the cell body. During the process extension, the horizontally oriented cell body (asterisks) exhibited the tangential movement toward the right hemisphere of the cerebellum at a significantly reduced rate of 3.8 μm/hr. Time interval (in minutes) is indicated on the bottom left of each photograph. Scale bar, 10 μm. The total distance traversed by the granule cell soma (B), the direction and distance traveled by the soma during each 5 min of the testing period (C), and the length/width ratio of the soma (D) were plotted as a function of elapsed time.

  1. The Journal of Neuroscience vol. 21 no. 2 527-540
Responses to This Article
Be the first to respond to this article
Advertisement