Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor Are Required Simultaneously for Survival of Dopaminergic Primary Sensory Neurons In Vivo

Table 2.

Counts of total and TH+ neuronal profiles in the nodose ganglion from newborn wild-type (+/+/+/+) andgdnf homozygous (+/+/−/−) mice

Genotype Total profile Change TH+ Change
(bdnf/gdnf) Number (n) (%) Number (n) (%)
(+/+)/(+/+) 8336  ± 758  (12) 0 303  ± 20  (23) 0
(+/+)/(−/−) 8264  ± 731  (10), NS −1 296  ± 23  (15), NS −2
  • Profile counts are shown as means ± SEM. Percent change is relative to wild-type.

  • NS, Not different from bdnf+/+gdnf+/+ (wild-type).

  1. The Journal of Neuroscience vol. 21 no. 2 581-589
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