Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor Are Required Simultaneously for Survival of Dopaminergic Primary Sensory Neurons In Vivo

Table 3.

Counts of TH+ neurons in the petrosal ganglion that coexpress RET from newborn wild-type (+/+/+/+),gdnf homozygous (+/+/−/−), bdnf homozygous (−/−/+/+), and bdnf/gdnf double homozygous (−/−/−/−) mice

Genotype Total profile Change
(bdnf/gdnf) Number (n) (%)
A. (+/+)/(+/+) 133  ± 12  (5) 0
B. (+/+)/(−/−) 33  ± 6  (5)3-a,3-b,3-c −75
C. (−/−)/(+/+) 47  ± 5  (4)3-a,3-b −65
D. (−/−)/(−/−) 2  ± 1  (5)3-a −98
  • Profile counts are shown as means ± SEM. Percent change is relative to wild-type.

  • ↵F3-a Differs frombdnf+/+gdnf+/+ (wild-type).

  • ↵F3-b Differs frombdnf−/−gdnf−/− (BDNF/GDNF double knock-out).

  • ↵F3-c Not different frombdnf−/−gdnf+/+ (BDNF knock-out).

  1. The Journal of Neuroscience vol. 21 no. 2 581-589
Responses to This Article
Be the first to respond to this article
Advertisement