Effects on alternation scores of intrahippocampal injections of glucose, glibenclamide, lemakalim, and lemakalim plus glucose or glibenclamide. Infusion of glucose (6.6 mm) or glibenclamide (100 μm) significantly enhanced spontaneous alternation scores above those of vehicle-infused controls. Infusion of lemakalim (200 μm) significantly impaired alternation scores relative to those of controls. Coadministration of either glucose or glibenclamide and lemakalim resulted in alternation scores not significantly different from those of controls. ♦p < 0.05 versus VEH, LEM/GLC, and LEM/GLB; *p < 0.05 versus GLC. Numberswithin bars indicate the number of rats per group included in data analysis.