Summary of functional properties of unitary IPSCs generated at the BC–BC synapse
| Mean ± SEM | [Range] (n) | |
|---|---|---|
| Unitary IPSCs1-a | ||
| Latency IPSC1-b | 0.8 ± 0.05 msec | [0.6–1.2] (14) |
| 20–80% rise time of IPSC1-b | 0.3 ± 0.02 msec | [0.2–0.46] (14) |
| Decay τw of IPSC1-b,1-c | 2.5 ± 0.2 msec | [1.1–3.8] (14) |
| Decay τ11-b,1-c | 1.6 ± 0.1 msec | [1.0–2.0] (11) |
| Decay τ21-b,1-c | 11.0 ± 2.3 msec | [3.7–26.7] (11) |
| Ampl. contr. fast comp.1-b,1-c | 76.8 ± 7.8% | [21–99] (11) |
| Peak amplitude IPSC1-b,1-d | 110 ± 19 pA | [34–234] (14) |
| Percentage of failures | 10 ± 5% | [0–48] (14) |
| Paired-pulse depression1-e | ||
| PPD at 10 msec | 32 ± 4.6% | [15–52] (17) |
| Recovery from PPD, τ | 0.63 sec | (17) |
| Multiple-pulse depression (50 Hz)1-e | ||
| Onset τ1 (ampl. contr.) | 0.025 sec (42%) | (3) |
| Onset τ2 (ampl. contr.) | 5.1 sec (37%) | (3) |
| Block of IPSCs1-e | ||
| 20 μmbicuculline | 94 ± 1% | [92–97] (4) |
| Inferred postsynaptic conductance change1-a | ||
| Rise τ | 0.17 ± 0.04 msec | [0.09–0.2] (3) |
| Decay τ | 1.8 ± 0.6 msec | [1.0–2.9] (3) |
| Peak amplitude (all sites)1-f | 7.6 ± 4.2 nS | [1.9–15.8] (3) |
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↵F1-a Data from rigorously identified BC–BC pairs.
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↵F1-b Values were determined from average IPSCs.
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↵F1-c Based on visual criteria, a biexponential fit was judged to be superior in 11 pairs (yielding time constant values τ1, τ2, and an amplitude-weighted decay time constant τw), whereas a monoexponential fit was adequate in the remaining 3 pairs (yielding a time constant τm). The overall value given is the mean of τw and τm values.
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↵F1-d Including failures.
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↵F1-e Data from both rigorously and tentatively identified BC–BC pairs.
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↵F1-f With the surface area of the somatodendritic domain of the reconstructed BCs (mean 12082 μm2), this would correspond to a mean conductance density of 0.063 mS/cm2.
