The Journal of NeuroscienceSociety for Neuroscience

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• ARTICLE
  • Cellular/Molecular

Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived Neurons

Fig. 6.

CEP-1347 promotes the growth of neurons in the absence of NGF. At 5 DIV sister cultures either were continued in 50 ng/ml NGF or were deprived of NGF in the presence of 500 nmCEP-1347. Somal diameters were measured as described in Materials and Methods.