CEP-1347 can abort the death process: commitment point and blockade of cytochrome c release.A, Neurons were maintained in NGF for 5 d and then deprived of NGF for the specified times. Then sister cultures were rescued with either NGF or CEP-1347 for 3 d, and viability was assessed. B, CEP-1347 can block cytochromec release acutely. Neurons were deprived of NGF for 12, 22, or 36 hr. Sister cultures were deprived of NGF for 22 hr and then rescued with either NGF or CEP-1347 for an additional 14 hr. At 36 hr,p < 0.01 for −NGF versus NGF rescue, −NGF versus CEP-1347 rescue.