CEP-1347 allows atrophic neurons once again to sequester cytochrome c mitochondrially. Neurons were grown in NGF for 5 d, at which time sister parallel cultures were deprived of NGF in the presence of BAF for 48 hr (−NGF+BAF). Then the deprived cultures were rescued with either NGF (NGF R) or CEP-1347 (CEP-1347 R). Both NGF and CEP-1347 treatments resulted in resequestration of mitochondrial cytochrome c;p < 0.01 for −NGF + GAF versus NGF R, −NGF + BAF versus CEP-1347 R.