Table 2.
PF-EPSC synaptic current fractions after application of Ca2+ channel-blocking toxins
| Toxins applied | ω-Aga-IVA (a) | ω-CgTx (b) | ω-Aga-IVA + ω-CgTx (c) | (a + b + c) |
|---|---|---|---|---|
| wt | 0.09 ± 0.01 (0.55) | 0.76 ± 0.04 (0.09) | 0.08 ± 0.01 (0.43) | (1.07) |
| tg | 0.17 ± 0.02 (0.45) | 0.43 ± 0.04 (0.24) | 0.19 ± 0.05 (0.56) | (1.25) |
| tgrol | 0.17 ± 0.02 (0.44) | 0.61 ± 0.05 (0.15) | 0.23 ± 0.03 (0.61) | (1.20) |
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Each value represents mean ± SEM of three or four measurements. Numbers in parentheses (a–c) are the estimated fractions of the Ca2+ channel subtypes mediating synaptic transmission, assuming a third power relation between presynaptic Ca2+ concentration and postsynaptic response amplitude.
