Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

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Fig. 6.
Fig. 6.

Immunofluorescence of 2-month-old YAC72 (line 44) and wild-type (WT) mice. A, In the cortex, Htt552 immunostaining (red) appears in a punctate pattern throughout the neuron, as confirmed by costaining with the neuronal marker NeuN (green).B, Immunofluorescence of the striatum from YAC72 (line 44) and wild-type mice at 2 months of age. Htt552 immunostaining (red) appears in a punctate pattern throughout the neuron, as confirmed by costaining with the neuronal marker NeuN (green). Htt552 staining was more abundant in the cortex than in the striatum. Scale bars, 2.5 μm.

  1. The Journal of Neuroscience vol. 22 no. 18 7862-7872
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