A, OEA blocked hyperphagia elicited by AEA (10 mg/kg) when injected 30 min before the endogenous cannabinoid in partially satiated rats. VEH, Vehicle.B, SR141716A (SR) potentiates the feeding suppression induced by OEA. The effects of a subthreshold dose of SR141716A (0.3 mg/kg, i.p.) on OEA (0.5, 1, and 5 mg/kg, i.p.) induced feeding suppression on food intake in 24 hr food-deprived rats 1 hr after the injection of OEA. Either vehicle (open bars) or SR141716A (black bars) was injected 30 min before OEA. Similar results were obtained 4 and 24 hr after the administration of drugs (data not shown). Data are the means ± SEM of at least 10 determinations per group. *p < 0.01 versus vehicle-treated group; Newman–Keuls.^#p < 0.01 versus 0 dose.