TUNEL immunoreactivity correlates with neurological scores. A, Low magnification showing TUNEL-reactive cells (revealed by FITC and depicted here inred) superimposed with Hoechst staining (showed here ingray) in the striatum. Note the strong TUNEL labeling that appears at 3-NP-5 days in the DL striatum.B, Higher magnification of TUNEL-positive cells showing apoptotic bodies (arrow) at day 5 of the 3-NP treatment showing fragmented nuclei (arrow). Right panel, Corresponding Hoechst staining. C, TUNEL-positive cells were counted in the striatum. The mean value was determined in group of 3-NP-treated rats presenting the same neurological score. <5, Three to 4 d of 3-NP treatment; 5–6, 5 d of treatment;7–8, 6 d of treatment. Statistical analysis: *p < 0.05 when comparing scores7–8 and <5 (Scheffé test).