Determining the functional stoichiometry of kainate receptor desensitization. a, Schematic of the tetramer model. b, GluR6 experimental records (dots; patch number 000720p2) fit with the concerted/independent (left, solid line) and tetramer (right, solid line) models. Entire 50 msec of three test responses (tc = 15, 135, and 285 msec) are superimposed for comparison. The dashed line indicates zero current level. c, Plot profiling the distribution of each state in the tetramer model at a range of interpulse intervals.d, Summary plots showing how fits of experimental data with different models of desensitization were compared. Fits were compared pairwise, using the F ratio test. Eachbar indicates the confidence level distinguishing between two models fit to the same experimental data. For every comparison seven bars are shown that represent the results from seven separate patch recordings. The dashed line in each plot denotes the 95% confidence level.
