The DIG group of proteins. Alignment of the deduced amino acid sequences of DPR (DPR1) and DPR2–20. The DPR1-related proteins were assigned numbers in descending order of the E values generated from the BLAST search (for E values and BDGP numbers, see Materials and Methods). The sequences of some of the putative DPR-related proteins, corresponding to portions of DPR1 residues 55–84, were not available and are indicated. Other sequences unavailable for DPR7, DPR11, DPR13, DPR14, and DPR19 are indicated byX symbols; however, the exact number of missing residues is not known. Gaps in some DPR proteins, relative to others, are represented by dashes. The double asterisks in the DPR15 and DPR20 represent possible insertions of 160 and 10 residues, respectively, not included in this alignment. The predicted cleavage site (after residue 32 in DPR) after the putative signal sequence (Nielsen et al., 1997) is indicated by thetriangle. The predicted transmembrane domain (TMD) (amino acids 276–293) is boxed. The numbers above the sequences show the running tally of amino acids in DPR1. The GenBank accession number for the DPR1 sequence is AF489698.