Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons

Table 1.

Changes in membrane potential, conductance, and variance with the UP state

State
Parameter In vitro In vivo/anesthetized In vivo/natural sleep/waking
DOWN-UP transition (mV) 4-10 10-15a 9.6b
10-15c
7.6 ± 2.1 14.6 ± 4.2d
Change in Gm (nS) 4-32 23e 27b
12.8 ± 7.8 74f
UP state noise (SD) (mV) 2.0-3.5 4-5a 2-3 UP state, REM sleep and wakingb
4 ± 2c
2.43 ± 0.57 2-3g
  • Values are either range or mean ± SD according to which of these was reported. REM, Rapid eye movement.

  • ↵ a Anderson et al. (2000a).

  • ↵ b Steriade et al. (2001), their Figures 5, 8, and 9.

  • ↵ c Destexhe and Pare (1999).

  • ↵ d Stern et al. (1997).

  • ↵ e Contreras et al. (1996), their Figures 2 and 3.

  • ↵ f Paré et al. (1998), their Figure 7.

  • ↵ g Metherate and Ashe (1993), their Figures 1 and 5.

  1. The Journal of Neuroscience vol. 23 no. 32 10388-10401
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